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Uncle – makes picking the best formulation or protein construct a piece of cake

The first all-in-one biologics stability screening platform.

Product Description

One-stop stability
Cracking stability using a pile of one-trick, protein-hungry tools is a ton of work. Uncle combines 3 different measurement modes — fluorescence, SLS and DLS. So you can crank out all your data in just a few hours, and use way less protein. All the info you’ll get makes picking the best formulation or protein construct a piece of cake.

 

Tm & Tagg

 

Tm with SYPRO (DSF)

 

Isothermal stability

 

Sizing & polydispersity

 

Sizing with thermal ramp

 

kD

 

B22

 

G22

 

Thermal recovery

 

Viscosity

 

ΔG

 

 

Unleash the Uni
Get more data with way less protein. The Uni only needs 9 μL of sample, and you pick how you use it. Run 1 sample in the morning, 48 in the afternoon. Do a DLS read if that’s all you need. Or, check DLS, then start a 3-day experiment to monitor real-time stability. Your samples are sealed airtight, so runs can be short or long — your call.

 

Full-spectrum
Biologics behave differently. With Uncle, you get the whole fluorescence spectrum, so you don’t need to know ahead of time how your protein behaves. If you want to try out some new tricks with dyes, Uncle can pick up on those too. Uncle catches aggregation with two wavelengths — so you’ll see it no matter what.

 

Uncover way more in one shot
Trying new formulations or constructs? Get answers for up to 48 samples in under 2 hours. Measure Tm and Tagg at the same time and know when unfolding leads to aggregation. Add a DLS read before the temp ramp to know if you’ve got aggregate trouble right out of the gate.

 

Isothermal stability
Uncle handles reading DLS, SLS, or both for days with no sample evaporation. So set your temp and walk away. Get a heads-up on long-term stability with the conditions that matter most to you.

 

Sizing with thermal ramp
Grab polydispersity, diameter, and size distribution with amped sensitivity. Then take the same samples and do a thermal ramp to measure which ones get bent out of shape and which keep their cool.

 

B22 & kD
Get B22 and kD at the same time in the same Uni. Change up excipients to see if your protein is better off or not — ASAP. Learn on the spot if your protein-formulation combo is good to go or risky for aggregation.

 

G22
At super high concentrations, most proteins become a mystery. G22 pulls back the curtain to show if concentration will create more aggregation problems for your proteins. The more negative your results are, the more repulsive the protein is.

 

 

For more information about Stunner- 96 DLS/UV-VIS spectrophotometer

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